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Alexander Fleischmann, PhD

Department of Neuroscience, Brown University

My laboratory is interested in how neural circuits generate sensory perception and behavior. We use a combination of molecular genetic, in vivo imaging, computational and behavioral approaches to determine fundamental functional properties of neural networks in the mouse olfactory cortex. I have joined the Brown Neuroscience Department in January 2018.

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The Lab

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Simon Daste

Graduate Student

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Nell Klimpert

Research Assistant

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Diego Rodriguez

Undergraduate Researcher

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Sara Zeppilli

Graduate Student

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Andrea Pierre

Software Engineer

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Zach Levin

Undergraduate Researcher

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Max Seppo

Graduate Student

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Alkim Kara

Undergraduate Researcher

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Robin Attey

Undergraduate Researcher

Selected Publications

Meissner-Bernard C, Dembitskaya Y, Venance L, Fleischmann A. Encoding of Odor Fear Memories in the Mouse Olfactory Cortex. Curr Biol. 2018 Dec 24. PMID:30612908 [pdf]

Roland B, Deneux T, Franks KM, Bathellier B, Fleischmann A. Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex. eLife, 2017 May 10;6. pii: e26337. PMCID: PMC5438249 [pdf]

Diodato A, Ruinart de Brimont M, Yim YS, Derian N, Perrin S, Pouch J, Klatzmann D, Garel S, Choi G, Fleischmann A (2016). Molecular signatures of neural connectivity in the olfactory cortex. Nature Commun., 18;7:12238. PMCID: PMC4960301 [pdf]

Choi GB, Stettler DD, Kallman BR, Bhaskar ST, Fleischmann A, Axel R (2011). Driving opposing behaviors with ensembles of piriform neurons. Cell, 146:1004-1015. PMCID: PMC3230930 [pdf]

Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, Franks KM, Schaefer AT, Fleischmann A (2016). Massive normalization of odor-evoked activity in the olfactory bulb of mice with a “monoclonal nose”. eLife, 2016 May 13;5. pii: e16335. PMCID: PMC4919110

Angelo K., Pimentel D., Pichler B., Fleischmann A., Rancz E., Margrie T. (2012). A biophysical signature of network affiliation and sensory processing in mitral cells. Nature, Aug16;488(7411):375-8. PMCID: PMC3442227 [pdf]

Glinka M.E., Samuels B.A., Teillon J., Mei D.F., Shykind B.M., Hen R., Fleischmann A. (2012). Olfactory deficits cause anxiety-like behaviors in mice. J. Neurosci., 32(19):6718-6725. PMCID: PMC3367161 [pdf]

Abdus-Saboor I., Al Nufal MJ, Agha MV, Ruinart de Brimont M, Fleischmann A., Shykind B (2016). Expression refinement ensures singular odorant receptor gene choice. Curr. Biol., 25;26(8):1083-90. PMID: 27040780 [pdf]

Fleischmann A., Abdus-Saboor I., Sayed A., Shykind B (2013). Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation. PLoS Biol., 11(5): e1001568. PMCID: PMC3660300 [pdf]

Fleischmann A., Shykind B.M., Sosulski D.L., Franks K.M, Glinka M.E., Mei D.F., Yonghua S., Kirkland J., Mendelsohn M., Albers M.W., Axel R. (2008). Mice with a "monoclonal" nose: perturbations in an olfactory map impair odor discrimination. Neuron, 60:1-14. PMCID: PMC2732586 [pdf]

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