Project 1:
Project 1:
The Osmonauts
Alexander Fleischmann, PhD
Department of Neuroscience, Brown University
My laboratory is interested in how neural circuits generate sensory perception and behavior. We use a combination of molecular genetic, in vivo imaging, computational and behavioral approaches to determine fundamental functional properties of neural networks in the mouse olfactory cortex. I have joined the Brown Neuroscience Department in January 2018.
The Lab
Simon Daste
Graduate Student
Nell Klimpert
Graduate student
Olivia McKissick
Graduate Student
Andrea Pierre
Software Engineer
Max Seppo
Graduate Student
Keeley Baker
Postdoctoral fellow
Tuan Pham
Software Engineer
Emily DeNunzio
Research assistant
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Camille Donoho
Undergraduate Researcher
Selected Publications
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Zeppilli S, Ortega Gurrola A, Demetci P, Brann D, Attey R, Zilkha N, Kimchi T, Datta SR, Singh R, Tosches MA, Crombach A, Fleischmann A
Mammalian olfactory cortex neurons retain molecular signatures of ancestral cell types. bioRxiv
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Zeppilli S, Ackels T, Attey R, Klimpert N, Ritola K, Boeing S, Crombach A, Schaefer A, Fleischmann A (2021)
Molecular characterization of projection neuron subtypes in the mouse olfactory bulb. Elife.
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Meissner-Bernard C, Dembitskaya Y, Venance L, Fleischmann A (2018)
Encoding of Odor Fear Memories in the Mouse Olfactory Cortex. Curr Biol.
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Roland B, Deneux T, Franks KM, Bathellier B, Fleischmann A.
Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex. eLife, 2017 May 10;6. pii: e26337. PMCID: PMC5438249 [pdf]
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Diodato A, Ruinart de Brimont M, Yim YS, Derian N, Perrin S, Pouch J, Klatzmann D, Garel S, Choi G, Fleischmann A (2016). Molecular signatures of neural connectivity in the olfactory cortex. Nature Commun., 18;7:12238. PMCID: PMC4960301 [pdf]
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Choi GB, Stettler DD, Kallman BR, Bhaskar ST, Fleischmann A, Axel R (2011). Driving opposing behaviors with ensembles of piriform neurons. Cell, 146:1004-1015. PMCID: PMC3230930 [pdf]
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Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, Franks KM, Schaefer AT, Fleischmann A (2016). Massive normalization of odor-evoked activity in the olfactory bulb of mice with a “monoclonal nose”. eLife, 2016 May 13;5. pii: e16335. PMCID: PMC4919110
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Angelo K., Pimentel D., Pichler B., Fleischmann A., Rancz E., Margrie T. (2012). A biophysical signature of network affiliation and sensory processing in mitral cells. Nature, Aug16;488(7411):375-8. PMCID: PMC3442227 [pdf]
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Glinka M.E., Samuels B.A., Teillon J., Mei D.F., Shykind B.M., Hen R., Fleischmann A. (2012). Olfactory deficits cause anxiety-like behaviors in mice. J. Neurosci., 32(19):6718-6725. PMCID: PMC3367161 [pdf]
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Abdus-Saboor I., Al Nufal MJ, Agha MV, Ruinart de Brimont M, Fleischmann A., Shykind B (2016). Expression refinement ensures singular odorant receptor gene choice. Curr. Biol., 25;26(8):1083-90. PMID: 27040780 [pdf]
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Fleischmann A., Abdus-Saboor I., Sayed A., Shykind B (2013). Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation. PLoS Biol., 11(5): e1001568. PMCID: PMC3660300 [pdf]
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Fleischmann A, Shykind BM, Sosulski DL, Franks KM, Glinka ME, Mei D.F, Yonghua S, Kirkland J, Mendelsohn M, Albers MW, Axel R (2008)
Mice with a "monoclonal" nose: perturbations in an olfactory map impair odor discrimination. Neuron, 60:1-14. PMCID: PMC2732586 [pdf]